Chemical Structure : S3I-1757
CAS No.:
1456602-51-9
S3I-1757
Catalog No.: PC-20628Not For Human Use, Lab Use Only.
S3I-1757 is a small molecule STAT3-STAT3 dimerization inhibitor with IC50 of 13.5 uM in fluorescence polarization (FP) assays, interacts with Y-705 binding site in the SH2 domain.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
S3I-1757 is a small molecule STAT3-STAT3 dimerization inhibitor with IC50 of 13.5 uM in fluorescence polarization (FP) assays, interacts with Y-705 binding site in the SH2 domain.
S3I-1757 disrupts intracellular STAT3-STAT3 dimerization and STAT3-EGFR binding in intact cells.
S3I-1757 (50-200 uM) decreases phosphotyrosine STAT3 levels in the nucleus of human MDA-MB-468 breast cancer cells, inhibits STAT3-DNA binding.
S3I-1757 (50-200 uM, 18h) inhibits STAT3-dependent transcriptional activity and decreases the expression of STAT3-regulated genes in MDA-MB-468 cells.
S3I-1757 inhibits anchorage-dependent proliferation selectively, and inhibits migration and invasion selectively in human cancers that harbor high levels of P-STAT3.
Physicochemical Properties
|
M.Wt
|
521.61
|
|
Formula
|
C33H31NO5
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
5-[[(4-Cyclohexylphenyl)methyl](4-phenoxybenzoyl)amino]-2-hydroxybenzoic acid
|
References
1. Zhang X, et al. Cancer Res. 2013 Mar 15;73(6):1922-33.
Contact Us
sales@probechem.com
