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Chemical Structure : S3I-201
CAS No.: 501919-59-1
Catalog No.: PC-20465Not For Human Use, Lab Use Only.
S3I-201 (NSC 74859) is a selective chemical probe inhibitor of Stat3 activity, inhibits Stat3 DNA-binding activity in vitro with IC50 of 86 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $58 | In stock | |
| 25 mg | $98 | In stock | |
| 50 mg | $158 | In stock | |
| 100 mg | $258 | In stock | |
| 250 mg | Get quote |
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S3I-201 (NSC 74859) is a selective chemical probe inhibitor of Stat3 activity, inhibits Stat3 DNA-binding activity in vitro with IC50 of 86 uM.
S3I-201 preferentially inhibits Stat3 DNA-binding activity over that of Stat1 and Stat5 (IC50, >300 and 166 uM respectively).
S3I-201 disrupts Stat3·Stat3 complex formation in vitro and in intact cells.
S3I-201 suppresses Stat3-dependent but not Stat3-independent transcriptional activity.
S3I-201 inhibits anchorage-dependent and -independent growth only of cells that contain persistently active Stat3.
S3I-201 (30 uM) inhibits cyclin D1, Bcl-xL, and survivin expression and induces apoptosis in a Stat3-dependent manner in breast carcinoma MDA-MB-435 cell line.
S3I-201 (5 mg/kg, i.v.) induces tumor regression in human breast (MDA-MB-231) tumor-bearing mice.
| M.Wt | 365.36 | |
| Formula | C16H15NO7S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Benzoic acid, 2-hydroxy-4-[[2-[[(4-methylphenyl)sulfonyl]oxy]acetyl]amino]- |
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1. Lin L, et al. Oncogene. 2009 Feb 19;28(7):961-72.
2. Siddiquee K, et al. Proc Natl Acad Sci U S A. 2007 May 1;104(18):7391-6.
3. Pang M, et al. Kidney Int. 2010 Aug;78(3):257-68.
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