Catalog No.: PC-20465Not For Human Use, Lab Use Only.
S3I-201 (NSC74859, S31-201) is a selective chemical probe inhibitor of Stat3 activity, inhibits Stat3 DNA-binding activity in vitro with IC50 of 86 uM.
S3I-201 (NSC74859, S31-201) is a selective chemical probe inhibitor of Stat3 activity, inhibits Stat3 DNA-binding activity in vitro with IC50 of 86 uM.
S3I-201 preferentially inhibits Stat3 DNA-binding activity over that of Stat1 and Stat5 (IC50, >300 and 166 uM respectively).
S3I-201 disrupts Stat3·Stat3 complex formation in vitro and in intact cells.
S3I-201 suppresses Stat3-dependent but not Stat3-independent transcriptional activity.
S3I-201 inhibits anchorage-dependent and -independent growth only of cells that contain persistently active Stat3.
S3I-201 (30 uM) inhibits cyclin D1, Bcl-xL, and survivin expression and induces apoptosis in a Stat3-dependent manner in breast carcinoma MDA-MB-435 cell line.
S3I-201 (5 mg/kg, i.v.) induces tumor regression in human breast (MDA-MB-231) tumor-bearing mice.
