S44563 is a potent, dual Bcl-2/Bcl-XL inhibitor with IC50 of 131 and 140 nM, respectively.
S44563 induces in vitro apoptosis of melanoma xenograft-derived cell lines MP41, MM26, and MM66 with IC50 of 4, 7 and 6 uM.
S44563 increases the efficacy of fotemustine in either concomitant or sequential combinations or indeed subsequent to fotemustine in vivo, also enhance radiosensitivity of SCLC cells in vitro and in vivo.
