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Chemical Structure : S44563
Catalog No.: PC-61989Not For Human Use, Lab Use Only.
S44563 is a potent, dual Bcl-2/Bcl-XL inhibitor with IC50 of 131 and 140 nM, respectively.
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S44563 is a potent, dual Bcl-2/Bcl-XL inhibitor with IC50 of 131 and 140 nM, respectively.
S44563 induces in vitro apoptosis of melanoma xenograft-derived cell lines MP41, MM26, and MM66 with IC50 of 4, 7 and 6 uM.
S44563 increases the efficacy of fotemustine in either concomitant or sequential combinations or indeed subsequent to fotemustine in vivo, also enhance radiosensitivity of SCLC cells in vitro and in vivo.
| M.Wt | 839.467 | |
| Formula | C44H47ClN6O5S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ashkenazi A, et al. Nat Rev Drug Discov. 2017 Apr;16(4):273-284.
2. Némati F, et al. PLoS One. 2014 Jan 13;9(1):e80836.
3. Loriot Y, et al. Cell Death Dis. 2014 Sep 18;5:e1423.
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