S6K2 inhibitor Compound 2

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Chemical Structure : S6K2 inhibitor Compound 2

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Catalog No.: PC-72701Not For Human Use, Lab Use Only.

S6K2 inhibitor Compound 2 is the first potent and highly isoform-specific S6K2 inhibitor with IC50 of 22 nM, inactive for the closely related isoform S6K1 at 5 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

S6K2 inhibitor Compound 2 is the first potent and highly isoform-specific S6K2 inhibitor with IC50 of 22 nM, inactive for the closely related isoform S6K1 at 5 uM.
S6K2 inhibitor Compound 2 did not show significant inhibitory activity against MAPKAPK2, MAPKAPK3, FGFR4, and TTK kinases, except for FGFR4 (IC50=216 nM).

Physicochemical Properties

M.Wt	561.954
Formula	C24H23ClF3N9O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(6-chloro-3-nitropyridin-2-yl)-5-ethyl-4-(4-((5-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)methyl)piperazin-1-yl)pyrimidin-2-amine

References

1. Stefan Gerstenecker, et al. Cancers (Basel). 2021 Oct 13;13(20):5133.

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