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Chemical Structure : SAG-524
Catalog No.: PC-21756Not For Human Use, Lab Use Only.
SAG-524 (SAG524) is a potent and orally bioavailable small molecule inhibitor of HBV replication, reduces HBsAg and HBV-DNA (IC50 = 0.92 nM and 1.4 nM) by destabilizing HBV-RNA.
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SAG-524 (SAG524) is a potent and orally bioavailable small molecule inhibitor of HBV replication, reduces HBsAg and HBV-DNA (IC50 = 0.92 nM and 1.4 nM) by destabilizing HBV-RNA.
SAG-524 selectively destabilizes HBV-RNA via PAPD5, but not GAPDH or albumin mRNA, by shortening the poly(A) tail.
SAG-524 produces potent reductions of serum HBsAg and HBcrAg, and the minimum effective dose of 6 mg/kg/day in HBV-infected PXB mice.
SAG-524 greatly reduces HBsAg and cccDNA in the liver due to reduction of human hepatocytes with good tolerability, when combined with entecavir.
| M.Wt | 594.13 | |
| Formula | C30H32ClN5O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Watanabe T, et al. J Gastroenterol. 2024 Feb 5. doi: 10.1007/s00535-023-02070-y.
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