Chemical Structure : SAK3
CAS No.:
1256269-87-0
SAK3
(T-VGCC enhancer SAK3)
Catalog No.: PC-36028Not For Human Use, Lab Use Only.
SAK3 (T-VGCC enhancer SAK3) is a potent, orally acitve enhancer of T-type voltage-gated Ca2+ channel (T-VGCC), enhances CaV3.1 and CaV3.3, but not CaV3.2 activity at concentrations of 0.01-10 nM in neuro2A cells in vitro.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
SAK3 (T-VGCC enhancer SAK3) is a potent, orally acitve enhancer of T-type voltage-gated Ca2+ channel (T-VGCC), enhances CaV3.1 and CaV3.3, but not CaV3.2 activity at concentrations of 0.01-10 nM in neuro2A cells in vitro; significantly enhanced acetylcholine (ACh) release in the hippocampal CA1 region of naïve mice (0.5 mg/kg, p.o.); significantly enhanced hippocampal ACh levels in olfactory-bulbectomized (OBX) mice, rescuing impaired memory-related behaviors.
Physicochemical Properties
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M.Wt
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369.421
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Formula
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C20H23N3O4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20 °C 12 Months; 4°C 6 Months
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- In Solvent
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-80 °C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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Ethyl 8'-methyl-2',4-dioxo-2-(piperidin-1-yl)-2'H-spiro[cyclopent[2]ene-1,3'-imidazo[1,2-a]pyridine]-3-carboxylate
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References
1. Yabuki Y, et al. Neuropharmacology. 2017 May 1;117:1-13.
2. Izumi H, et al. Neuroscience. 2018 May 1;377:87-97.
3. Husain N, et al. Pharmacology. 2018;101(5-6):309-321.
4. Wang S, et al. PLoS One. 2018 Dec 20;13(12):e0206986.
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