Chemical Structure : SALAD1
CAS No.:
SALAD1
Catalog No.: PC-25296Not For Human Use, Lab Use Only.
SALAD1 is a cell-permeable ultrabright RNA-activated fluorophore, facilitates improved in-cell confocal RNA imaging, binds to Mango II in a distinctive manner.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
SALAD1 is a cell-permeable ultrabright RNA-activated fluorophore, facilitates improved in-cell confocal RNA imaging, binds to Mango II in a distinctive manner.
SALAD1 exhibitsa 3.5-fold improved brightness relative to TO1–biotin, which is typically used in cellular imaging with Mango aptamers.
SALAD1 (KDapp =0.69 ±0.1 nM) binds 7.5-fold more tightly to Mango II compared to TO (KDapp =5.9 ±1.4 nM).
SALAD1 exhibits a binding preference to its target RNA (Mango II) over the other three Mango aptamers (7-, 20- and 16-fold tighter than Mango I, III and IV.
Physicochemical Properties
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M.Wt
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522.62
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Formula
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C30H25FN5OS+
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(E)-3-(2-((2-fluoro-6-(1H-pyrazol-1-yl)benzyl)amino)-2-oxoethyl)-2-((1-methylquinolin-4(1H)-ylidene)methyl)benzo[d]thiazol-3-ium
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References
1. Mo Yang, et al. Nat Chem. 2025 Aug;17(8):1188-1195. doi: 10.1038/s41557-025-01832-w.
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