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Chemical Structure : SALL4 peptide FFW
Catalog No.: PC-35369Not For Human Use, Lab Use Only.
SALL4 peptide FFW (RRKFAKFQWI, FFW peptide) is a potent therapeutic SALL4 peptide antagonist of SALL4-NURD (nucleosome remodeling deacetylase) interaction with target affinity of 23 nM.
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SALL4 peptide FFW (RRKFAKFQWI, FFW peptide) is a potent therapeutic SALL4 peptide antagonist of SALL4-NURD (nucleosome remodeling deacetylase) interaction with target affinity of 23 nM; reverses Transcription Repression by SALL4-RBBp4, disrupts the SALL4-NuRD complex resulted in unidirectional up-regulation of transcripts, turning SALL4 from a dual transcription repressor-activator mode to singular transcription activator mode; displays significant antitumor effects, inhibiting tumor growth by 85% in xenograft mouse models of HCC.
| M.Wt | 1378.697 | |
| Formula | C67H103N21O11 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Liu BH, et al. Proc Natl Acad Sci U S A. 2018 Jul 5. pii: 201801253.
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