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SAR-100842

Chemical Structure : SAR-100842

CAS No.: 1195941-38-8

SAR-100842 (Fipaxalparant, SAR100842)

Catalog No.: PC-35275Not For Human Use, Lab Use Only.

Fipaxalparant (SAR100842) is a potent, selective, orally available antagonist of the Lysophosphatidic Acid 1 Receptor (LPA1 receptor) with IC50 of 31 nM in β-arrestin assays.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Fipaxalparant (SAR100842) is a potent, selective, orally available antagonist of the Lysophosphatidic Acid 1 Receptor (LPA1 receptor) with IC50 of 31 nM in β-arrestin assays.
Fipaxalparant (SAR100842) demonstrates potential for the treatment of systemic sclerosis and related fibrotic diseases.

Physicochemical Properties

M.Wt 445.515
Formula C27H27NO5
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-{4-methoxy-3-[2-(3-methylphenyl)ethoxy]benzamido}-2,3-dihydro-1H-indene-2-carboxylic acid

References

1. Ellery J, et al. Eur J Pharmacol. 2018 May 26;833:8-15.

2. Kihara Y, et al. Exp Cell Res. 2015 May 1;333(2):171-7.

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