Catalog No.: PC-61100Not For Human Use, Lab Use Only.
SAS-0132 (SAS132) is a novel potent, subtype-selective, brain penetrant sigma 2 receptor/PGRMC1 ligand with Ki of 90 nM, 9-fold selectivity over sigma 1 receptors.
SAS-0132 (SAS132) is a novel potent, subtype-selective, brain penetrant sigma 2 receptor/PGRMC1 ligand with Ki of 90 nM, 9-fold selectivity over sigma 1 receptors.
SAS-0132 also exhibits low off-target affinity for most CNS-relevant targets, including opioid, adrenergic, nACR, mAChR, and NMDA receptors.
SAS-0132 modulates intracellular Ca2+ levels in human SK-N-SH neuroblastoma cells, and is neuroprotective in a C. elegans model of amyloid precursor protein-mediated neurodegeneration, improves cognitive performance in transgenic mouse model of AD.
