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Chemical Structure : SAV13
Catalog No.: PC-21137Not For Human Use, Lab Use Only.
SAV13 is a selective small molecule inhibitor of S. aureus exoprotein expression regulator (SaeR) withEC50 of 1.06 uM in luciferase assays, reduces expression of hla and other virulence factors.
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SAV13 is a selective small molecule inhibitor of S. aureus exoprotein expression regulator (SaeR) withEC50 of 1.06 uM in luciferase assays, reduces expression of hla and other virulence factors.
SAV13 interacts with the amino acid E159 of SaeR protein.
SAV13 inhibits hla expression in the USA300 strain with EC50 around 3 µM, and 10 µM in the agrA deletion mutant, while around 80 µM in saeR or saeS deletion strains.
SAV13 supresses S. aureus pathogenesis by inhibiting the expression of virulence factors without any killing effect.
SAV13 demonstrates in vivo effectiveness against S. aureus infection in mice.
| M.Wt | 423.22 | |
| Formula | C19H13Cl2FN2O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Peng Gao, et al. Emerg Microbes Infect. 2023 Sep 6;2254415.
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