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SB-216

Chemical Structure : SB-216

CAS No.: 2756818-39-8

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SB-216 (SB216)

Catalog No.: PC-25918Not For Human Use, Lab Use Only.

SB-216 is a potent and brain-penetrable tubulin inhibitor, inhibits cell growth and migration, and induces apoptosis with low nanomolar potencies in breast cancer brain metastasis (BCBM) models.

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10 mg $148 In stock
25 mg $258 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

SB-216 is a potent and brain-penetrable tubulin inhibitor, inhibits cell growth and migration, and induces apoptosis with low nanomolar potencies in breast cancer brain metastasis (BCBM) models.

Physicochemical Properties

M.Wt 310.36
Formula C17H18N4O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

7-Methoxy-4-(2-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)-3,4-dihydroquinoxalin-2(1H)-one

References

1. Krutilina RI, et al. Mol Cancer Ther. 2025 Nov 24. doi: 10.1158/1535-7163.MCT-25-0538.

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