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Chemical Structure : SB-242235
CAS No.: 193746-75-7
Catalog No.: PC-45452Not For Human Use, Lab Use Only.
SB-242235 is a selective p38 MAPK inhibitor, inhibits IL-1 beta induction of p38 MAPK in primary human chondrocytes with IC50 of 1 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $78 | In stock | |
| 10 mg | $118 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $358 | In stock | |
| 100 mg | Get quote |
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SB-242235 is a selective p38 MAPK inhibitor, inhibits IL-1 beta induction of p38 MAPK in primary human chondrocytes with IC50 of 1 uM.
SB-242235 inhibits LPS-stimulated serum levels of TNFalpha in normal rats with mean ED50 of 3.99 mg/kg.
| M.Wt | 353.3934 | |
| Formula | C19H20FN5O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 48 mg/mL |
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| Chemical Name/SMILES |
Pyrimidine, 4-[4-(4-fluorophenyl)-1-(4-piperidinyl)-1H-imidazol-5-yl]-2-methoxy- |
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1. Badger AM, et al. Osteoarthritis Cartilage. 2000 Nov;8(6):434-43.
2. Badger AM, et al. Arthritis Rheum. 2000 Jan;43(1):175-83.
3. Ward KW, et al. Xenobiotica. 2002 Mar;32(3):221-33.
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