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SB-242235

Chemical Structure : SB-242235

CAS No.: 193746-75-7

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SB-242235 (SB 242235, SB242235)

Catalog No.: PC-45452Not For Human Use, Lab Use Only.

SB-242235 is a selective p38 MAPK inhibitor, inhibits IL-1 beta induction of p38 MAPK in primary human chondrocytes with IC50 of 1 uM.

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5 mg $78 In stock
10 mg $118 In stock
25 mg $218 In stock
50 mg $358 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

SB-242235 is a selective p38 MAPK inhibitor, inhibits IL-1 beta induction of p38 MAPK in primary human chondrocytes with IC50 of 1 uM.
SB-242235 inhibits LPS-stimulated serum levels of TNFalpha in normal rats with mean ED50 of 3.99 mg/kg.

Physicochemical Properties

M.Wt 353.3934
Formula C19H20FN5O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 48 mg/mL
Chemical Name/SMILES

Pyrimidine, 4-[4-(4-fluorophenyl)-1-(4-piperidinyl)-1H-imidazol-5-yl]-2-methoxy-

References

1. Badger AM, et al. Osteoarthritis Cartilage. 2000 Nov;8(6):434-43.

2. Badger AM, et al. Arthritis Rheum. 2000 Jan;43(1):175-83.

3. Ward KW, et al. Xenobiotica. 2002 Mar;32(3):221-33.

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