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SB-357134

Chemical Structure : SB-357134

CAS No.: 219963-52-7

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SB-357134 (SB 357134, SB357134)

Catalog No.: PC-61178Not For Human Use, Lab Use Only.

SB-357134 is a potent, selective, orally active and CNS penetrant 5-HT6 receptor antagonist with pKi of 8.5, displays 1300-fold selectivity over other 13 5-HT receptor subtypes.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    SB-357134 is a potent, selective, orally active and CNS penetrant 5-HT6 receptor antagonist with pKi of 8.5, displays 1300-fold selectivity over other 13 5-HT receptor subtypes.
    SB-357134 inhibits 5-HT-stimulated cAMP accumulation in with pA2 of 7.63.
    SB-357134 enhances memory and learning following chronic administration in mice.

    Physicochemical Properties

    M.Wt 523.22
    Formula C17H18Br2FN3O3S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(2,5-dibromo-3-fluorophenyl)-4-methoxy-3-(piperazin-1-yl)benzene-1-sulfonamide

    References

    1. Bromidge SM, et al. Bioorg Med Chem Lett. 2001 Jan 8;11(1):55-8.

    2. Stean TO, et al. Pharmacol Biochem Behav. 2002 Apr;71(4):645-54.

    3. Marcos B, et al. Eur J Neurosci. 2006 Sep;24(5):1299-306.

    4. Rogers DC, et al. Psychopharmacology (Berl). 2001 Nov;158(2):114-9.

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