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Chemical Structure : SB-399885
CAS No.: 402713-80-8
Catalog No.: PC-63483Not For Human Use, Lab Use Only.
SB-399885 is a potent, selective, brain penetrant 5-HT6 receptor antagonist with pKi of 9.11 and 9.02 for human recombinant and native 5-HT6 receptors.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $88 | In stock | |
| 10 mg | $128 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $358 | In stock | |
| 100 mg | Get quote |
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SB-399885 is a potent, selective, brain penetrant 5-HT6 receptor antagonist with pKi of 9.11 and 9.02 for human recombinant and native 5-HT6 receptors.
SB-399885 is a potent competitive antagonist (pA(2)=7.85), displays over 200-fold selectivity over other receptors.
SB-399885 significantly increases extracellular acetylcholine levels in rat medial prefrontal cortex, exhibits cognitive enhancing properties in recognition models.
SB-399885 also is an inhibitor of HCV entry in liver-derived cell lines as well as primary hepatocytes, modulates localization of the coreceptor tight junction protein claudin-1 (CLDN1) in a 5-HT6-independent manner, induces intracellular accumulation of CLDN1.
| M.Wt | 446.343 | |
| Formula | C18H21Cl2N3O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
N-(3,5-dichloro-2-methoxyphenyl)-4-methoxy-3-piperazin-1-ylbenzenesulfonamide |
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1. Wesołowska A, et al. Eur J Pharmacol. 2008 Mar 17;582(1-3):88-93.
2. Riva L, et al. J Virol. 2018 Apr 27;92(10). pii: e01982-17.
3. Hirst WD, et al. Eur J Pharmacol. 2006 Dec 28;553(1-3):109-19.
4. Wesołowska A, et al. Neuropharmacology. 2007 Apr;52(5):1274-83.
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