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Chemical Structure : SB-612111
Catalog No.: PC-61547Not For Human Use, Lab Use Only.
SB-612111 is a potent, selective nociceptin/orphanin FQ receptor (NOP receptor) antagonist with Ki of 0.33 nM.
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SB-612111 is a potent, selective nociceptin/orphanin FQ receptor (NOP receptor) antagonist with Ki of 0.33 nM.
SB-612111 shows weak or little affinity for μ-, κ- and δ-receptors with Ki of 57.6, 160.5 and 2109 nM, respectively.
SB-612111 antagonizes the pronociceptive action of nociceptin in an acute pain model, and potentiates the action of morphine in morphine-tolerant animals and blocks hyperalgesia in an inflammatory pain model.
| M.Wt | 418.398 | |
| Formula | C24H29Cl2NO | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Zaratin PF, et al. J Pharmacol Exp Ther. 2004 Feb;308(2):454-61.
2. Rizzi A, et al. J Pharmacol Exp Ther. 2007 Jun;321(3):968-74.
3. Spagnolo B, et al. J Pharmacol Exp Ther. 2007 Jun;321(3):961-7.
4. Marti M, et al. Br J Pharmacol. 2013 Feb;168(4):863-79.
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