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SB-612111 hydrochloride

Chemical Structure : SB-612111 hydrochloride

CAS No.: 371980-94-8

SB-612111 hydrochloride (SB 612111, SB612111)

Catalog No.: PC-60800Not For Human Use, Lab Use Only.

SB-612111 hydrochloride is a potent, selective opiate receptor-like orphan receptor (ORL-1, NOP) antagonist with Ki of 0.33 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    SB-612111 hydrochloride is a potent, selective opiate receptor-like orphan receptor (ORL-1, NOP) antagonist with Ki of 0.33 nM.
    SB-612111 displays good selectivity versus mu-(174-fold), delta-(6391-fold), and kappa (486-fold)-opioid receptors.
    SB-612111 antagonizes the antimorphine action of nociceptin (ED50= 0.69 mg/kg) with no measurable antinociceptive effects in vivo.
    SB-612111 antagonizes nociceptin-induced thermal hyperalgesia (ED50=0.62 mg/kg i.v.) in rat carrageenan inflammatory pain model.

    Physicochemical Properties

    M.Wt 454.86
    Formula C24H29Cl2NO.HCl
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    7-[[4-(2,6-Dichlorophenyl)-1-piperidinyl]methyl]-6,7,8,9-tetrahydro-1-methyl-5H-benzocyclohepten-5-ol hydrochloride

    References

    1. Liao YY, et al. Eur J Pharmacol. 2011 Apr 25;657(1-3):84-8.

    2. Spagnolo B, et al. J Pharmacol Exp Ther. 2007 Jun;321(3):961-7.

    3. Rizzi A, et al. J Pharmacol Exp Ther. 2007 Jun;321(3):968-74.

    4. Zaratin PF, et al. J Pharmacol Exp Ther. 2004 Feb;308(2):454-61.

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