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SB-699393

Chemical Structure : SB-699393

CAS No.: 1348166-93-7

SB-699393 (SB699393)

Catalog No.: PC-63027Not For Human Use, Lab Use Only.

SB-699393 (SB699393) is a potent, selective and CNS penetrant B-Raf inhibitor with Kd of 7.2 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    SB-699393 (SB699393) is a potent, selective and CNS penetrant B-Raf inhibitor with Kd of 7.2 nM.
    SB-699393 possesses enhanced CNS penetration (BB ratio=0.8:1) compared with SB-590885.

    Physicochemical Properties

    M.Wt 403.482
    Formula C24H25N3O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (E)-((5-(5-(morpholinomethyl)-2-(pyridin-4-yl)furan-3-yl)-2,3-dihydro-1H-inden-1-ylidene)amino)methanol

    References

    1. Takle AK, et al. Bioorg Med Chem Lett. 2008 Aug 1;18(15):4373-6.

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