SB-710411 | Urotensin II receptor ligand

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Chemical Structure : SB-710411

SB-710411 (SB710411)

Catalog No.: PC-28270Not For Human Use, Lab Use Only.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

SB-710411 is a selective peptidic urotensin-II receptor (UTR, U-II receptor, GPR14) antagonist, inhibits [(125)I]urotensin-II rat and monkey UT receptor binding with pKi of 7.50 and 6.85 respectively.
SB-710411 inhibits hU-II-induced contraction in rat isolated aorta causing a significant, parallel shift in the agonist concentration-response curve (pK(b) 6.28.
SB-710411 antagonizes urotensin-II-induced inositol phosphate formation at the rat UT receptor (pK(b) 6.54).
SB-710411 functions as an agonist at the monkey UT receptor (pEC(50) 6.56).

Physicochemical Properties

M.Wt	1146.22
Formula	C54H66Cl2N12O8S2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Cpa-c[D-Cys-Pal-D-Trp-Lys-Val-Cys]-Cpa-amide

References

1. Behm DJ, et al. Br J Pharmacol. 2002 Oct;137(4):449-58.

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SB-710411 (SB710411)

Biological Activity

Physicochemical Properties

References

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