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Chemical Structure : SB203580
CAS No.: 152121-47-6
Catalog No.: PC-42491Not For Human Use, Lab Use Only.
SB203580 (Adezmapimod, RWJ 64809) is a specific p38 MAPK inhibitor with IC50 of 0.6 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg (Free Sample) | $28 | In stock | |
| 25 mg | $98 | In stock | |
| 50 mg | $148 | In stock | |
| 100 mg | Get quote |
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SB203580 (Adezmapimod, RWJ 64809) is a specific p38 MAPK inhibitor with IC50 of 0.6 uM.
SB 203580 shows selectivity over JNK, p42 MAPK, p90 S6K, p70 S6K, PKA, etc..
SB 203580 suppresses the activation of MAPKAP kinase-2 and prevents the phosphorylation of HSP27 in response to interleukin-1, cellular stresses and bacterial endotoxin in vivo.
| M.Wt | 377.4346 | |
| Formula | C21H16FN3OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 33 mg/mL |
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| Chemical Name/SMILES |
Pyridine, 4-[4-(4-fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-5-yl]- |
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1. Cuenda A, et al. FEBS Lett. 1995 May 8;364(2):229-33.
2. Lali FV, et al. J Biol Chem. 2000 Mar 10;275(10):7395-402.
3. Badger AM, et al. J Pharmacol Exp Ther. 1996 Dec;279(3):1453-61.
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