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SB203580

Chemical Structure : SB203580

CAS No.: 152121-47-6

SB203580 (Adezmapimod, RWJ 64809;SB 203580, SB-203580)

Catalog No.: PC-42491Not For Human Use, Lab Use Only.

SB203580 (Adezmapimod, RWJ 64809) is a specific p38 MAPK inhibitor with IC50 of 0.6 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

SB203580 (Adezmapimod, RWJ 64809) is a specific p38 MAPK inhibitor with IC50 of 0.6 uM.
SB 203580 shows selectivity over JNK, p42 MAPK, p90 S6K, p70 S6K, PKA, etc..
SB 203580 suppresses the activation of MAPKAP kinase-2 and prevents the phosphorylation of HSP27 in response to interleukin-1, cellular stresses and bacterial endotoxin in vivo.

Physicochemical Properties

M.Wt 377.4346
Formula C21H16FN3OS
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 33 mg/mL

Chemical Name/SMILES

Pyridine, 4-[4-(4-fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-5-yl]-

References

1. Cuenda A, et al. FEBS Lett. 1995 May 8;364(2):229-33.

2. Lali FV, et al. J Biol Chem. 2000 Mar 10;275(10):7395-402.

3. Badger AM, et al. J Pharmacol Exp Ther. 1996 Dec;279(3):1453-61.

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