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SB 203580 hydrochloride

Chemical Structure : SB 203580 hydrochloride

CAS No.: 869185-85-3

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SB 203580 hydrochloride (RWJ 64809 hydrochloride;SB203580 hydrochloride;SB-203580 hydrochloride)

Catalog No.: PC-42492Not For Human Use, Lab Use Only.

A specific p38 MAPK inhibitor with IC50 of 0.6 uM.

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50 mg $64 In stock
100 mg $96 In stock
200 mg $168 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

A specific p38 MAPK inhibitor with IC50 of 0.6 uM; shows selectivity over JNK, p42 MAPK, p90 S6K, p70 S6K, PKA, etc.; suppresses the activation of MAPKAP kinase-2 and prevents the phosphorylation of HSP27 in response to interleukin-1, cellular stresses and bacterial endotoxin in vivo.

Physicochemical Properties

M.Wt 413.8956
Formula C21H17ClFN3OS
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
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Solubility

H2O: 8.43 mg/mL
Chemical Name/SMILES

Pyridine, 4-[4-(4-fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-5-yl]-, hydrochloride (1:1)

References

1. Cuenda A, et al. FEBS Lett. 1995 May 8;364(2):229-33.

2. Lali FV, et al. J Biol Chem. 2000 Mar 10;275(10):7395-402.

3. Badger AM, et al. J Pharmacol Exp Ther. 1996 Dec;279(3):1453-61.

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