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Chemical Structure : SB204990
CAS No.: 154566-12-8
Catalog No.: PC-62188Not For Human Use, Lab Use Only.
SB204990 is the cell-penetrant, orally active gamma-lactone prodrug of the potent ATP citrate-lyase (ACLY) inhibitor SB-201076.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $198 | In stock | |
| 25 mg | $328 | In stock | |
| 50 mg | $548 | In stock | |
| 100 mg | Get quote |
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SB204990 is the cell-penetrant, orally active gamma-lactone prodrug of the potent ATP citrate-lyase (ACLY) inhibitor SB-201076.
SB204990 inhibits cholesterol and fatty acid synthesis in HepG2 cells and reduces plasma triglyceride levels in vivo.
SB204990 induces clear hypocholesterolemic and hypotriglyceridaemic responses in rats.
| M.Wt | 389.27 | |
| Formula | C18H22Cl2O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
(3R,5S)-rel-5-[6-(2,4-Dichlorophenyl)hexyl]tetrahydro-3-hydroxy-2-oxo-3-furanacetic acid |
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1. Pearce NJ, et al. Biochem J. 1998 Aug 15;334 ( Pt 1):113-9.
2. Bracha AL, et al. Nat Chem Biol. 2010 Mar;6(3):202-204.
3. Hatzivassiliou G, et al. Cancer Cell. 2005 Oct;8(4):311-21.
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