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SB 206553

Chemical Structure : SB 206553

CAS No.: 1197334-04-5

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SB 206553 (SB206553)

Catalog No.: PC-62760Not For Human Use, Lab Use Only.

SB 206553 is a potent and selective 5-HT2B/5-HT2C receptor antagonist with pA2 of 8.89 for rat 5-HT2B, pKi of 7.92 for human 5-HT2C, displays >80-fold selectivity over other 5-HT receptor subtypes.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    SB 206553 is a potent and selective 5-HT2B/5-HT2C receptor antagonist with pA2 of 8.89 for rat 5-HT2B, pKi of 7.92 for human 5-HT2C, displays >80-fold selectivity over other 5-HT receptor subtypes.
    SB 206553 exhibits anxiolytic-like properties both in vitro and in vivo.

    Physicochemical Properties

    M.Wt 328.80
    Formula C17H17ClN4O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    3,5-Dihydro-5-methyl-N-3-pyridinylbenzo[1,2-b:4,5-b']dipyrrole-1(2H)-carboxamide hydrochloride

    References

    1. Forbes IT, et al. J Med Chem. 1995 Jul 7;38(14):2524-30.

    2. Upton N, et al. Eur J Pharmacol. 1998 Oct 16;359(1):33-40.

    3. Kennett GA, et al. Br J Pharmacol. 1996 Feb;117(3):427-434.

    4. Porras G, et al. Neuropsychopharmacology. 2002 Mar;26(3):311-24.

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