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SB 224289 hydrochloride

Chemical Structure : SB 224289 hydrochloride

CAS No.: 180084-26-8

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SB 224289 hydrochloride (SB-224289)

Catalog No.: PC-38596Not For Human Use, Lab Use Only.

SB 224289 hydrochloride is a potent, selective 5-HT1B inverse agonist/antagonist with pKi value of 8.16, displays >75-fold selectivity over all other 5-HT receptors.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

SB 224289 hydrochloride is a potent, selective 5-HT1B inverse agonist/antagonist with pKi value of 8.16, displays >75-fold selectivity over all other 5-HT receptors.
SB 224289 is a potent antagonist of terminal 5-HT autoreceptor function both in vitro and in vivo.

Physicochemical Properties

M.Wt 557.091
Formula C32H33ClN4O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Methanone, [2′-methyl-4′-(5-methyl-1,2,4-oxadiazol-3-yl)[1,1′-biphenyl]-4-yl](2,5,6,7-tetrahydro-1′-methylspiro[3H-furo[2,3-f]indole-3,4′-piperidin]-5-yl)-, hydrochloride (1:1)

References

1. Gaster LM, et al. J Med Chem. 1998 Apr 9;41(8):1218-35.

2. Pauwels PJ, et al. Br J Pharmacol. 1998 Jan;123(1):51-62.

3. Verheggen R, et al. Br J Pharmacol. 1998 Aug;124(7):1345-54.

4. J V Selkirk, et al. Br J Pharmacol. 1998 Sep;125(1):202-8.

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