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SB 239063

Chemical Structure : SB 239063

CAS No.: 193551-21-2

SB 239063 (SB-239063, SB239063)

Catalog No.: PC-42803Not For Human Use, Lab Use Only.

SB 239063 is a potent, selective, orally available p38 MAPK inhibitor with IC50 of 44 nM for both p38α and p38β.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

SB 239063 is a potent, selective, orally available p38 MAPK inhibitor with IC50 of 44 nM for both p38α and p38β.
SB 239063 shows no activity (>100 μM) against the γ- and δ-kinase isoforms, and a panel of protein kinase.
SB 239063 inhibits IL-1 and TNF-alpha production in LPS-stimulated human PBMCs (IC50= 0.12 and 0.35 uM).
SB 239063 reduces inflammatory cytokine production, airways eosinophil infiltration and persistence in vivo.

Physicochemical Properties

M.Wt 368.4048
Formula C20H21FN4O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Cyclohexanol, 4-[4-(4-fluorophenyl)-5-(2-methoxy-4-pyrimidinyl)-1H-imidazol-1-yl]-, trans-

References

1. Underwood DC, et al. J Pharmacol Exp Ther. 2000 Apr;293(1):281-8.

2. Underwood DC, et al. Am J Physiol Lung Cell Mol Physiol. 2000 Nov;279(5):L895-902.

3. Barone FC, et al. J Pharmacol Exp Ther. 2001 Feb;296(2):312-21.

4. Legos JJ, et al. Brain Res. 2001 Feb 16;892(1):70-7.

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