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Chemical Structure : SB 239063
CAS No.: 193551-21-2
Catalog No.: PC-42803Not For Human Use, Lab Use Only.
SB 239063 is a potent, selective, orally available p38 MAPK inhibitor with IC50 of 44 nM for both p38α and p38β.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 1 mg (Free Sample) | $28 | In stock | |
| 5 mg | $98 | In stock | |
| 10 mg | $148 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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SB 239063 is a potent, selective, orally available p38 MAPK inhibitor with IC50 of 44 nM for both p38α and p38β.
SB 239063 shows no activity (>100 μM) against the γ- and δ-kinase isoforms, and a panel of protein kinase.
SB 239063 inhibits IL-1 and TNF-alpha production in LPS-stimulated human PBMCs (IC50= 0.12 and 0.35 uM).
SB 239063 reduces inflammatory cytokine production, airways eosinophil infiltration and persistence in vivo.
| M.Wt | 368.4048 | |
| Formula | C20H21FN4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
Cyclohexanol, 4-[4-(4-fluorophenyl)-5-(2-methoxy-4-pyrimidinyl)-1H-imidazol-1-yl]-, trans- |
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1. Underwood DC, et al. J Pharmacol Exp Ther. 2000 Apr;293(1):281-8.
2. Underwood DC, et al. Am J Physiol Lung Cell Mol Physiol. 2000 Nov;279(5):L895-902.
3. Barone FC, et al. J Pharmacol Exp Ther. 2001 Feb;296(2):312-21.
4. Legos JJ, et al. Brain Res. 2001 Feb 16;892(1):70-7.
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