SB 269970 hydrochloride | 5-HT7 antagonist

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Chemical Structure : SB 269970 hydrochloride

SB 269970 hydrochloride (SB-269970 hydrochloride)

Catalog No.: PC-22278Not For Human Use, Lab Use Only.

SB269970 (SB-269970) hydrochloride is a potent, selective 5-HT7 receptor antagonist with pKi of 8.9, >100-fold selective over other 5-HT receptors.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

SB269970 (SB-269970) hydrochloride is a potent, selective 5-HT7 receptor antagonist with pKi of 8.9, >100-fold selective over other 5-HT receptors.
SB-269970 (0.03-1 microM) inhibited the 5-CT concentration-response with no significant alteration in the maximal response.

Physicochemical Properties

M.Wt	388.95
Formula	C18H29ClN2O3S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-3-((2-(2-(4-Methylpiperidin-1-yl)ethyl)pyrrolidin-1-yl)sulfonyl)phenol hydrochlorid

References

1. Roberts C, et al. Br J Pharmacol. 2001 Apr;132(7):1574-80.

2. Hagan JJ, et al. Br J Pharmacol. 2000 Jun;130(3):539-48.

3. Lovell PJ, et al. J Med Chem. 2000 Feb 10;43(3):342-5.

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SB 269970 hydrochloride (SB-269970 hydrochloride)

Biological Activity

Physicochemical Properties

References

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