Catalog No.: PC-63171Not For Human Use, Lab Use Only.
SBC-115076 is a PCSK9 inhibitor that blocks LDLR degradation in HEK293T cells expressing PCSK9, increase the uptake of LDL by liver cells in vitro at submicromolar concentrations.
SBC-115076 is a PCSK9 inhibitor that blocks LDLR degradation in HEK293T cells expressing PCSK9, increase the uptake of LDL by liver cells in vitro at submicromolar concentrations.
SBC-115076 effectively lowers cholesterol levels in high fat diet mice.
1. Daniel Pettersen, et al. Small molecule modulators of PCSK9-a literature and patent overview. Bioorg Med Chem Lett. 2018 Feb 26. pii: S0960-894X(18)30151-3.
