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Chemical Structure : SBI-0206965
CAS No.: 1884220-36-3
Catalog No.: PC-45106Not For Human Use, Lab Use Only.
SBI-0206965 (SBI 0206965) is a potent and specific small molecule ULK1 kinase inhibitor with IC50 of 108 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $118 | In stock | |
| 10 mg | $178 | In stock | |
| 25 mg | $288 | In stock | |
| 50 mg | $478 | In stock | |
| 100 mg | Get quote |
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SBI-0206965 (SBI 0206965) is a potent and specific small molecule ULK1 kinase inhibitor with IC50 of 108 nM.
SBI-0206965 displays 7-fold less potency for ULK2 (IC50=711 nM).
SBI-0206965 inhibits Beclin1 Ser15 and Vps34 Ser249 phosphorylation to comparable extents in HEK-293T cells。
SBI-0206965 suppresses autophagy induced by mTOR inhibition and prevents ULK1-dependent cell survival。
SBI-0206965 greatly synergizes with mTOR inhibitors to kill tumor cells.
| M.Wt | 489.3192 | |
| Formula | C21H21BrN4O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-((5-bromo-2-((3,4,5-trimethoxyphenyl)amino)pyrimidin-4-yl)oxy)-N-methylbenzamide |
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1. Egan DF, et al. Mol Cell. 2015 Jul 16;59(2):285-97.
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