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Chemical Structure : SBI-0637142
Catalog No.: PC-72432Not For Human Use, Lab Use Only.
SBI-0637142 is a potent Smac mimetic that preferentially targets BIRC2, latency-reversing agent (LRA), specifically and potently promote HIV-1 latency reversal activity.
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SBI-0637142 is a potent Smac mimetic that preferentially targets BIRC2, latency-reversing agent (LRA), specifically and potently promote HIV-1 latency reversal activity.
SBI-0637142 modestly induced HIV-1 latency ex vivo in CD4+ T cells from ART-suppressed aviremic HIV-infected patients as a single agent, showed robust activity when administered in combination with the HDACi panobinostat.
SBI-0637142's latency reversal activity is dependent on the NIK-dependent NF-κB signaling.
| M.Wt | 472.648 | |
| Formula | C25H36N4O3S | |
| Appearance | Solid | |
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1. Pache L, et al. Cell Host Microbe. 2015;18:345-353.
2. Lars Pache, et al. Cell Rep Med. 2020 Jun 23;1(3):100037.
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