Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : SBI-553
CAS No.: 1849603-72-0
Catalog No.: PC-38142Not For Human Use, Lab Use Only.
SBI-553 (SBI553) is a potent, selective, β-arrestin-biased, brain penetrant neurotensin receptor 1 (NTR1, NTSR1) allosteric modulator with EC50 of 0.34 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $188 | In stock | |
| 10 mg | $298 | In stock | |
| 25 mg | $498 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
SBI-553 (SBI553) is a potent, selective, β-arrestin-biased, brain penetrant neurotensin receptor 1 (NTR1, NTSR1) allosteric modulator with EC50 of 0.34 uM.
SBI-553 had no effect on the potency of NT in the NTR1 high-content (β-arrestin2-GFP) assay.
SBI-553 not only acts as a β-arrestin-biased agonist but also extends profound β-arrestin bias to the endogenous ligand by selectively antagonizing G protein signaling.
SBI-553 only showed moderate affinity against a range of related and unrelated GPCRs using the same high-content assay format (NTR2, GPR35, GPR55, K-opioid).
SBI-553 (12 mg/kg, i.p.) attenuated basal hyperlocomotion in dopamine transporter knockout (DAT−/−) mice.
SBI-553 showed efficacy in animal models of psychostimulant abuse, including cocaine self-administration, without the side effects characteristic of balanced NTSR1 agonism.
| M.Wt | 450.558 | |
| Formula | C26H31FN4O2 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
2-((2-(1-Fluorocyclopropyl)-4-(4-(2-methoxyphenyl)piperidin-1-yl)quinazolin-6-yl)(methyl)amino)ethan-1-ol |
|
1. Pinkerton AB, et al. J Med Chem. 2019 Sep 12;62(17):8357-8363.
2. Slosky LM, et al. Cell. 2020 Jun 11;181(6):1364-1379.e14.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
