SBP-0636457 | IAP antagonist | Probechem Biochemicals

Chemical Structure : SBP-0636457

SBP-0636457 (SBI-0636457)

Catalog No.: PC-27418Not For Human Use, Lab Use Only.

SBP-0636457 (SBI-0636457) is a SMAC mimetic and IAP antagonist, binds to the BIR-domains of the IAP proteins with Ki of 0.27 uM, sensitizes cancer cells to TRAIL-induced apoptosis.

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Biological Activity

SBP-0636457 (SBI-0636457) is a SMAC mimetic and IAP antagonist, binds to the BIR-domains of the IAP proteins with Ki of 0.27 uM, sensitizes cancer cells to TRAIL-induced apoptosis.

Physicochemical Properties

M.Wt	456.59
Formula	C25H36N4O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(4S,7S,9aS)-8,8-Dimethyl-4-((S)-2-(methylamino)propanamido)-5-oxo-N-((R)-1,2,3,4-tetrahydronaphthalen-1-yl)octahydropyrrolo[2,1-b][1,3]oxazepine-7-carboxamide

References

1. Finlay D, et, al. Mol Cancer Ther. 2014 Jan; 13(1): 5-15.

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SBP-0636457 (SBI-0636457)

Biological Activity

Physicochemical Properties

References

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