Catalog No.: PC-28553Not For Human Use, Lab Use Only.
SBP-5917 is a potent, selective reversible, orally bioavailable inhibitor of thioesterase (TE) domain of fatty acid synthase (FASN) (FASN-TE) with IC50 of 120 nM in OMFH assays.
SBP-5917 is a potent, selective reversible, orally bioavailable inhibitor of thioesterase (TE) domain of fatty acid synthase (FASN) (FASN-TE) with IC50 of 120 nM in OMFH assays.
SBP-5917 is more active than the R-enantiomer 78R.
SBP-5917 shows EC50 of 220 nM in CETSA thermal profiles.
SBP-5917 selectively inhibit FASN in cellular lysates, blocks the production of palmitate in SK-Mel5 cells with IC50 of 2.7 uM, simultaneously induces the de novo synthesis of stearate, a fatty acid with 18 carbons, with EC50 of 0.14 uM.
SBP-5917 binds to the full length FASN protein in addition to the recombinantly purified TE domain.
