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SC-236

Chemical Structure : SC-236

CAS No.: 170569-86-5

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SC-236 (SC236, SC58236)

Catalog No.: PC-61664Not For Human Use, Lab Use Only.

SC-236 (SC58236) is a potent, selective, orally active inhibitor of COX-2 with IC50 of 10 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

SC-236 (SC58236) is a potent, selective, orally active inhibitor of COX-2 with IC50 of 10 nM.
SC-236 displays >1,700-fold selectivity over COX-1 (IC50=17.8 uM).
SC-236 exhibits anti-inflammatory properties and potent antimetastatic activity both in vitro and in vivo.

Physicochemical Properties

M.Wt 401.8
Formula C16H11ClF3N3O2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-[5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-benzenesulfonamide

References

1. Penning TD, et al. J Med Chem. 1997 Apr 25;40(9):1347-65.

2. Lee A, et al. Cancer Res. 2006 Apr 15;66(8):4378-84.

3. Roche-Nagle G, et al. Br J Cancer. 2004 Jul 19;91(2):359-65.

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