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Chemical Structure : SC-560
CAS No.: 188817-13-2
Catalog No.: PC-22979Not For Human Use, Lab Use Only.
SC-560 is a potent, highly specfiic, orally active cyclooxygenase type 1 (COX-1) inhibitor with IC50 of 9 nM, >500-fold selective over COX-2.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $98 | In stock | |
| 25 mg | $158 | In stock | |
| 50 mg | $258 | In stock | |
| 100 mg | Get quote |
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SC-560 is a potent, highly specfiic, orally active cyclooxygenase type 1 (COX-1) inhibitor with IC50 of 9 nM, >500-fold selective over COX-2.
SC-560 inhibited COX-1-derived platelet thromboxane B2, gastric PGE2, and dermal PGE2 production, but not COX-2-derived PGs in the lipopolysaccharide-induced rat air pouch.
SC-560 reduced paw PGs to equivalent levels in rat carrageenan footpad model.
| M.Wt | 352.74 | |
| Formula | C17H12ClF3N2O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole |
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1. Smith CJ, et al. Proc Natl Acad Sci U S A. 1998 Oct 27;95(22):13313-8.
2. Wallace JL, et al. Gastroenterology. 2000 Sep;119(3):706-14.
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