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SC-68448

Chemical Structure : SC-68448

CAS No.: 188804-07-1

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SC-68448 (SC68448)

Catalog No.: PC-35693Not For Human Use, Lab Use Only.

SC-68448 (SC68448) is a potent, selective peptidomimetic antagonist of the integrin αvβ3 with IC50 of 1 nM, 100-fold selectivity over αIIbβ3.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

SC-68448 (SC68448) is a potent, selective peptidomimetic antagonist of the integrin αvβ3 with IC50 of 1 nM, 100-fold selectivity over αIIbβ3.
SC-68448 inhibits alpha(v)beta3-mediated endothelial cell proliferation in a dose-dependent manner but did not inhibit tumor cell proliferation in cell-based assays; inhibits angiogenesis in vivo in a basic fibroblast growth factor-induced rat corneal neovascularization model.

Physicochemical Properties

M.Wt 452.292
Formula C19H19Cl2N5O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Benzenepropanoic acid, beta-[[2-[[3-[(aminoiminomethyl)amino]benzoyl]amino]acetyl]amino]-3,5-dichloro-

References

1. Carron CP, et al. Cancer Res. 1998 May 1;58(9):1930-5.

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