Chemical Structure : SC428
CAS No.:
1898232-70-6
SC428
(SC 428, SC-428)
Catalog No.: PC-20758Not For Human Use, Lab Use Only.
SC428 (SC-428) is a small molecule androgen receptor (AR) signaling inhibitor, directly binds to the AR N-terminal domain (NTD) and exhibits pan-AR inhibitory effect.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
SC428 (SC-428) is a small molecule androgen receptor (AR) signaling inhibitor, directly binds to the AR N-terminal domain (NTD) and exhibits pan-AR inhibitory effect.
SC428 potently decreased the transactivation of AR-V7, ARv567es, as well as full-length AR (AR-FL) and its LBD mutants.
SC428 substantially suppressed androgen-stimulated AR-FL nuclear translocation, chromatin binding, and AR-regulated gene transcription.
SC428 significantly attenuated AR-V7–mediated AR signaling that does not rely on androgen, hampered AR-V7 nuclear localization, and disrupted AR-V7 homodimerization.
SC428 inhibited in vitro proliferation and in vivo tumor growth of cells that expressed a high level of AR-V7 and were unresponsive to enzalutamide (ENZ) treatment.
Physicochemical Properties
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M.Wt
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337.32
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Formula
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C15H10F3N3OS
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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O=C(N/C=C/C1=CC=CS1)NC2=CC=C(C#N)C(C(F)(F)F)=C2
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References
1. Yi Q, et al. Mol Cancer Ther. 2023 May 4;22(5):570-582.
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