Chemical Structure : SCC944
CAS No.:
880041-28-1
SCC944
(MCULE-5095997944, SCC-944)
Catalog No.: PC-27291Not For Human Use, Lab Use Only.
SCC944 (MCULE-5095997944) is a small molecule ARF1-CSW modulator, binds directly to ARF1 (SPR KD=167 nM) and reduces GTP-bound ARF1 levels upon ARF1 activation.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
SCC944 (MCULE-5095997944) is a small molecule ARF1-CSW modulator, binds directly to ARF1 (SPR KD=167 nM) and reduces GTP-bound ARF1 levels upon ARF1 activation.
SCC944 antagonizes ARF1 activation, significantly suppresses the active GTP-bound ARF1 levels.
SCC944 interacts with various residues in ARF1, SMCR8, and C9orf72 proteins.
SCC944 demonstrated brefeldin A-like ARF1-dependent alteration of organelle organization including Golgi, microtubules, and mitochondria, but also a protein trafficking pattern that is distinct from brefeldin A mechanism.
The C9orf72 protein forms a complex with SMCR8 and WDR41 (CSW), which functions as a GTPase-activating protein (GAP) regulating ARF1 and RAB small GTPases.
Physicochemical Properties
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M.Wt
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368.78
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Formula
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C18H13ClN4O3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(E)-N-(4-chlorophenyl)-2-oxo-2-(2-((2-oxo-1,2-dihydroquinolin-3-yl)methylene)hydrazineyl)acetamide
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References
1. Dixon E, et al. bioRxiv [Preprint]. 2026 Jul 1:2026.01.24.701325.
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