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SCH-28080

Chemical Structure : SCH-28080

CAS No.: 76081-98-6

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SCH-28080 (SCH28080)

Catalog No.: PC-62890Not For Human Use, Lab Use Only.

SCH-28080 is a potent, orally active, reversible inhibitor of gastric H+,K+-ATPase with IC50 of 20 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

SCH-28080 is a potent, orally active, reversible inhibitor of gastric H+,K+-ATPase with IC50 of 20 nM; competitively inhibits the K+-stimulated hydrolysis of ATP catalyzed by the H+,K+-ATPase with Ki of 0.12 uM; inhibits gastric ulcers provoked by aspirin, aspirin+ acid, indomethacin and stress (cold-restraint) in rats (1-30 mg/kg p.o.), shows gastric antisecretory and cytoprotective activities.

Physicochemical Properties

M.Wt 277.33
Formula C17H15N3O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-Methyl-8-(phenylmethoxy)-imidazo[1,2-a]pyridine-3-acetonitrile

References

1. Vagin O, et al. Biochemistry. 2002 Oct 22;41(42):12755-62.

2. Long JF, et al. J Pharmacol Exp Ther. 1983 Jul;226(1):114-20.

3. Scott CK, et al. Biochem Pharmacol. 1987 Jan 1;36(1):97-104.

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