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SCH221510

Chemical Structure : SCH221510

CAS No.: 322473-89-2

SCH221510 (SCH-221510)

Catalog No.: PC-60797Not For Human Use, Lab Use Only.

SCH221510 is a potent, selective, orally active nociceptin opioid receptor (NOP) agonist with EC50 of 12 nM, Ki of 0.3 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    SCH221510 is a potent, selective, orally active nociceptin opioid receptor (NOP) agonist with EC50 of 12 nM, Ki of 0.3 nM.
    SCH221510 displays >50-fold over the mu-, kappa-, and delta-opioid receptors.
    SCH221510 produces anxiolytic-like effects in rats, does not disrupt overt behavior.

    Physicochemical Properties

    M.Wt 397.562
    Formula C28H31NO
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    8-[bis(2-methylphenyl)-methyl]-3-phenyl-8-azabicyclo[3.2.1]octan-3-ol

    References

    1. Varty GB, et al. J Pharmacol Exp Ther. 2008 Aug;326(2):672-82.

    2. Sobczak M, et al. J Pharmacol Exp Ther. 2014 Mar;348(3):401-9.

    3. Cremeans CM, et al. J Pharmacol Exp Ther. 2012 Oct;343(1):72-81.

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