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Chemical Structure : SCH 351125
CAS No.: 370893-06-4
Catalog No.: PC-70235Not For Human Use, Lab Use Only.
SCH 351125 (Ancriviroc) is a small molecule inhibitor of HIV-1 entry via the CCR5 coreceptor.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $348 | In stock | |
| 10 mg | $548 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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SCH 351125 (Ancriviroc) is a small molecule inhibitor of HIV-1 entry via the CCR5 coreceptor.
SCH 351125 (Ancriviroc) specifically inhibits HIV-1 infection mediated by CCR5 in U-87 astroglioma cells but has no effect on infection of CXCR4-expressing cells.
SCH 351125 (Ancriviroc) has broad and potent antiviral activity in vitro against primary HIV-1 isolates with IC50 of 0.4-9 nM.
SCH 351125 (Ancriviroc) strongly inhibits the replication of an R5-using HIV-1 isolate in SCID-hu Thy/Liv mice; has a favorable pharmacokinetic profile and orally bioavailable.
| M.Wt | 557.533 | |
| Formula | C28H37BrN4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(Z)-3-(4-((4-bromophenyl)(ethoxyimino)methyl)-4'-methyl-[1,4'-bipiperidine]-1'-carbonyl)-2,4-dimethylpyridine 1-oxide |
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1. Strizki JM, et al. Proc Natl Acad Sci U S A. 2001 Oct 23;98(22):12718-23.
2. Palani A, et al. J Med Chem. 2001 Oct 11;44(21):3339-42.
3. Tremblay CL, et al. Antimicrob Agents Chemother. 2002 May;46(5):1336-9.
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