SCH 351125 |CAS:370893-06-4 Probechem Biochemicals

Chemical Structure : SCH 351125

CAS No.: 370893-06-4

SCH 351125 (SCH-C;SCH351125;Ancriviroc)

Catalog No.: PC-70235Not For Human Use, Lab Use Only.

SCH 351125 (Ancriviroc) is a small molecule inhibitor of HIV-1 entry via the CCR5 coreceptor.

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Biological Activity

SCH 351125 (Ancriviroc) is a small molecule inhibitor of HIV-1 entry via the CCR5 coreceptor.
SCH 351125 (Ancriviroc) specifically inhibits HIV-1 infection mediated by CCR5 in U-87 astroglioma cells but has no effect on infection of CXCR4-expressing cells.
SCH 351125 (Ancriviroc) has broad and potent antiviral activity in vitro against primary HIV-1 isolates with IC50 of 0.4-9 nM.
SCH 351125 (Ancriviroc) strongly inhibits the replication of an R5-using HIV-1 isolate in SCID-hu Thy/Liv mice; has a favorable pharmacokinetic profile and orally bioavailable.

Physicochemical Properties

M.Wt	557.533
Formula	C28H37BrN4O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(Z)-3-(4-((4-bromophenyl)(ethoxyimino)methyl)-4'-methyl-[1,4'-bipiperidine]-1'-carbonyl)-2,4-dimethylpyridine 1-oxide

References

1. Strizki JM, et al. Proc Natl Acad Sci U S A. 2001 Oct 23;98(22):12718-23.

2. Palani A, et al. J Med Chem. 2001 Oct 11;44(21):3339-42.

3. Tremblay CL, et al. Antimicrob Agents Chemother. 2002 May;46(5):1336-9.

SCH 351125 (SCH-C;SCH351125;Ancriviroc)

Biological Activity

Physicochemical Properties

References

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