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Chemical Structure : SCH 486757
Catalog No.: PC-60798Not For Human Use, Lab Use Only.
SCH 486757 is a potent, selective, orally active nociceptin/orphanin FQ peptide (NOP, ORL1) receptor agonist with Ki of 4.6 nM, with high selectiivity over classical opioid receptors.
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SCH 486757 is a potent, selective, orally active nociceptin/orphanin FQ peptide (NOP, ORL1) receptor agonist with Ki of 4.6 nM, with high selectiivity over classical opioid receptors.
SCH 486757 effectively suppresses cough in guinea pig capsaicin cough model, without affect on inspiratory electromyogram amplitude.
| M.Wt | 440.368 | |
| Formula | C24H23Cl2N3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. McLeod RL, et al. Eur J Pharmacol. 2010 Mar 25;630(1-3):112-20.
2. Woodcock A, et al. Lung. 2010 Jan;188 Suppl 1:S47-52.
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