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SCH 486757

Chemical Structure : SCH 486757

CAS No.: 524019-25-8

SCH 486757 (SCH-486757;SCH486757)

Catalog No.: PC-60798Not For Human Use, Lab Use Only.

SCH 486757 is a potent, selective, orally active nociceptin/orphanin FQ peptide (NOP, ORL1) receptor agonist with Ki of 4.6 nM, with high selectiivity over classical opioid receptors.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    SCH 486757 is a potent, selective, orally active nociceptin/orphanin FQ peptide (NOP, ORL1) receptor agonist with Ki of 4.6 nM, with high selectiivity over classical opioid receptors.
    SCH 486757 effectively suppresses cough in guinea pig capsaicin cough model, without affect on inspiratory electromyogram amplitude.

    Physicochemical Properties

    M.Wt 440.368
    Formula C24H23Cl2N3O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    8-(bis(2-chlorophenyl)methyl)-3-(pyrimidin-2-yl)-8-azabicyclo[3.2.1]octan-3-ol

    References

    1. McLeod RL, et al. Eur J Pharmacol. 2010 Mar 25;630(1-3):112-20.

    2. Woodcock A, et al. Lung. 2010 Jan;188 Suppl 1:S47-52.

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