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SCH 900229

Chemical Structure : SCH 900229

CAS No.: 1100361-36-1

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SCH 900229 (SCH900229)

Catalog No.: PC-62793Not For Human Use, Lab Use Only.

SCH 900229 is a potent and presenilin 1 selective, and orally active inhibitor of γ-secretase (Aβ40 IC50=1.3 nM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    SCH 900229 is a potent and presenilin 1 selective, and orally active inhibitor of γ-secretase (Aβ40 IC50=1.3 nM).
    SCH 900229 demonstrates excellent lowering of Aβ in preclinical animal models.

    Physicochemical Properties

    M.Wt 506.96
    Formula C21H21ClF2O6S2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (4S,4aS,10bS)-10b-[(4-Chlorophenyl)sulfonyl]-7,10-difluoro-1,4a,5,10b-tetrahydro-4-[2-(methylsulfonyl)ethyl]-2H,4H-pyrano[3,4-c][1]benzopyran

    References

    1. Wu WL, et al. ACS Med Chem Lett. 2012 Apr 9;3(11):892-6.

    2. Wu WL, et al. Bioorg Med Chem Lett. 2016 Dec 1;26(23):5836-5841.

    3. Wu WL, et al. Bioorg Med Chem Lett. 2016 Dec 1;26(23):5836-5841.

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