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Chemical Structure : SCH 900229
Catalog No.: PC-62793Not For Human Use, Lab Use Only.
SCH 900229 is a potent and presenilin 1 selective, and orally active inhibitor of γ-secretase (Aβ40 IC50=1.3 nM).
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SCH 900229 is a potent and presenilin 1 selective, and orally active inhibitor of γ-secretase (Aβ40 IC50=1.3 nM).
SCH 900229 demonstrates excellent lowering of Aβ in preclinical animal models.
| M.Wt | 506.96 | |
| Formula | C21H21ClF2O6S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Wu WL, et al. ACS Med Chem Lett. 2012 Apr 9;3(11):892-6.
2. Wu WL, et al. Bioorg Med Chem Lett. 2016 Dec 1;26(23):5836-5841.
3. Wu WL, et al. Bioorg Med Chem Lett. 2016 Dec 1;26(23):5836-5841.
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