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Chemical Structure : SCH900271
Catalog No.: PC-21426Not For Human Use, Lab Use Only.
SCH900271 is a potent nicotinic acid receptor GPR109A agonist with EC50 of 2 nM in hu-GPR109a assays.
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SCH900271 is a potent nicotinic acid receptor GPR109A agonist with EC50 of 2 nM in hu-GPR109a assays.
SCH900271 displays cross-species activity with EC50 of 8.0, 6.0 and 5.0 nM for rat-GPR109a, m-GPR109a and pig-GPR109a, respectively.
SCH900271 exhibits dose-dependent inhibition of plasma free fatty acid (FFA) with 50% FFA reduction at 1.0 mg/kg in fasted male beagle dogs.
SCH900271 shows no overt signs of flushing at doses up to 10 mg/kg with an improved therapeutic window to flushing as compared to nicotinic acid.
| M.Wt | 276.29 | |
| Formula | C14H16N2O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Anandan Palani, et al. ACS Med Chem Lett. 2011 Nov 24;3(1):63-8.
2. Brett Lauring, et al. Sci Transl Med. 2012 Aug 22;4(148):148ra115.
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