SCH900271 | GPR109A agonist | Probechem Biochemicals

Chemical Structure : SCH900271

SCH900271 (SCH 900271)

Catalog No.: PC-21426Not For Human Use, Lab Use Only.

SCH900271 is a potent nicotinic acid receptor GPR109A agonist with EC50 of 2 nM in hu-GPR109a assays.

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Biological Activity

SCH900271 is a potent nicotinic acid receptor GPR109A agonist with EC50 of 2 nM in hu-GPR109a assays.
SCH900271 displays cross-species activity with EC50 of 8.0, 6.0 and 5.0 nM for rat-GPR109a, m-GPR109a and pig-GPR109a, respectively.
SCH900271 exhibits dose-dependent inhibition of plasma free fatty acid (FFA) with 50% FFA reduction at 1.0 mg/kg in fasted male beagle dogs.
SCH900271 shows no overt signs of flushing at doses up to 10 mg/kg with an improved therapeutic window to flushing as compared to nicotinic acid.

Physicochemical Properties

M.Wt	276.29
Formula	C14H16N2O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(3-(1-methylcyclopropyl)propyl)-2H-pyrano[2,3-d]pyrimidine-2,4,7(1H,3H)-trione

References

1. Anandan Palani, et al. ACS Med Chem Lett. 2011 Nov 24;3(1):63-8.

2. Brett Lauring, et al. Sci Transl Med. 2012 Aug 22;4(148):148ra115.

SCH900271 (SCH 900271)

Biological Activity

Physicochemical Properties

References

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