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Chemical Structure : SCO-267
Catalog No.: PC-72109Not For Human Use, Lab Use Only.
SCO-267 (SCO267) is a potent, orally available GPR40/FFAR1 full agonist with EC50 of 12 nM (hGPR40).
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SCO-267 (SCO267) is a potent, orally available GPR40/FFAR1 full agonist with EC50 of 12 nM (hGPR40).
SCO-267 activated Gq signaling in both high- and low-FFAR1-expressing CHO cells, increased insulin, glucagon, GLP-1, glucose-dependent insulinotropic peptide, and peptide YY (PYY) secretions under nonfasting conditions in rats, induced GLP-1 secretion, food intake inhibition, and body weight reduction in mice.
SCO-267 effectively stimulated insulin secretion and GLP-1 release and ameliorated glucose tolerance in diabetic rats via GPR40 full agonism.
| M.Wt | 614.787 | |
| Formula | C36H46N4O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Hikaru Ueno, et al. J Pharmacol Exp Ther. 2019 Aug;370(2):172-181.
2. Hideki Furukawa, et al. J Med Chem. 2020 Sep 24;63(18):10352-10379.
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