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Chemical Structure : SCR2682
Catalog No.: PC-49538Not For Human Use, Lab Use Only.
SCR2682 is a potent, selective neuronal voltage-gated potassium Kv7/KCNQ/M channel opener (activator) with EC50 of 9.8 nM (Kv7.2/Kv7.3), 100-fold more potency than retigabine.
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SCR2682 is a potent, selective neuronal voltage-gated potassium Kv7/KCNQ/M channel opener (activator) with EC50 of 9.8 nM (Kv7.2/Kv7.3), 100-fold more potency than retigabine.
SCR2682 shifts voltage-dependent activation of the Kv7.2/7.3 current toward more negative membrane potential, to about −37 mV (V1/2).
SCR2682 also activates the native M-current in rat hippocampal or cortical neurons, causing marked hyperpolarization and potent inhibition of neuronal firings.
Intraperitoneal or intragastric administration of SCR2682 results in a dose-dependent inhibition of seizures by maximal electroshock.
SCR2682 also decreases epileptiform discharges in KA-induced seizures
| M.Wt | 435.424 | |
| Formula | C21H27BrN2OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Wang J, et al. J Pharmacol Exp Ther. 2021 Apr;377(1):20-28.
2. Zhuang XF, et al. J Pharmacol Exp Ther. 2022 Nov 17:JPET-AR-2022-001328.
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