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SCY-078

Chemical Structure : SCY-078

CAS No.: 1207753-03-4

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SCY-078 (Ibrexafungerp, MK-3118, SCY078)

Catalog No.: PC-60411Not For Human Use, Lab Use Only.

Ibrexafungerp (MK 3118, SCY-078) is a novel orally bioavailable fungal beta-1,3-D glucan synthetase inhibitor against Candida species C. glabrata (MIC 0.03 to 0.25 ug/ml), C. parapsilosis (MIC 0.06 to 0.25 ug/ml).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Ibrexafungerp (MK 3118, SCY-078) is a novel orally bioavailable fungal beta-1,3-D glucan synthetase inhibitor against Candida species C. glabrata (MIC 0.03 to 0.25 ug/ml), C. parapsilosis (MIC 0.06 to 0.25 ug/ml).
Ibrexafungerp (MK 3118, SCY-078) shows actvity in an in vivo neutropenic murine model.

Physicochemical Properties

M.Wt 730.05
Formula C44H67N5O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(1S,2R,3R,4aR,6aS,7R,8R,10aR,10bR,12aR)-2-((R)-2-amino-2,3,3-trimethylbutoxy)-1,6a,8,10a-tetramethyl-8-((R)-3-methylbutan-2-yl)-3-(5-(pyridin-4-yl)-1H-1,2,4-triazol-1-yl)-1,3,4,6,6a,7,8,9,10,10a,10b,11,12,12a-tetradecahydro-2H-1,4a-(methanooxymethano)chry

References

1. Wring SA, et al. Antimicrob Agents Chemother. 2017 Mar 24;61(4). pii: e02068-16.

2. Lamoth F, et al. Antimicrob Agents Chemother. 2015 Jul;59(7):4308-11.

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