SD-1029 |CAS:118372-34-2 Probechem Biochemicals

Chemical Structure : SD-1029

SD-1029 (SD1029;NSC 371488)

Catalog No.: PC-61666Not For Human Use, Lab Use Only.

SD-1029 (NSC 371488) is a potent inhibitor of Stat3 activation, suppresses EGFP-Stat3 nuclear translocation at 10 uM in both BHK-21 and U2-OS cells.

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Biological Activity

SD-1029 (NSC 371488) is a potent inhibitor of Stat3 activation, suppresses EGFP-Stat3 nuclear translocation at 10 uM in both BHK-21 and U2-OS cells.
SD-1029 inhibits Stat3-mediated antiapoptotic protein expression (Bcl-XL, MCL-1, and survivin), and suppresses phosphotyrosine levels of JAK2.
SD-1029 inhibits IL-6 or oncostatin-induced Stat3 nuclear translocation at micromolar range, enhances apoptosis induced by paclitaxel in human cancer cells.

Physicochemical Properties

M.Wt	639.3
Formula	C25H30Cl2N2O3 • 2HBr
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	9-(3,4-dichlorophenyl)-2,7-bis[(dimethylamino)methyl]-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione, dihydrobromide

References

1. Duan Z, et al. Clin Cancer Res. 2006 Nov 15;12(22):6844-52.

2. Yang C, et al. Mol Cancer Ther. 2009 Sep;8(9):2597-605.

3. Che Mat NF, et al. J Interferon Cytokine Res. 2011 Apr;31(4):363-71.

SD-1029 (SD1029;NSC 371488)

Biological Activity

Physicochemical Properties

References

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