Catalog No.: PC-49249Not For Human Use, Lab Use Only.
SD133 (Sd-133) is a drug-like small molecule inhibitor of adhesion molecule cadherin 11 (CDH11), binds specifically to the CDH11 binding pocket with KD of 25.2 uM in SPR assays.
SD133 (Sd-133) is a drug-like small molecule inhibitor of adhesion molecule cadherin 11 (CDH11), binds specifically to the CDH11 binding pocket with KD of 25.2 uM in SPR assays.
Sd-133 significantly inhibits the growth of all three CDH11 positive cell lines with an EC50 of 3 μM but has little effect on CDH11 negative MCF7 cells.
Sd-133 also inhibits MDA-MB-231 matrigel™ outgrowth at 1 μM but is inactive on control MDA-MB-435 melanoma cells (express N-cadherin) or MCF7 breast cancer cells that express E and P-cadherin.
Sd-133 inhibitsMDA-MB-231 colony formation.
SD133 (40 mg/kg and 10 mg/kg, i.p.) significantly reduces growth of pre-existing tumors in a dose-dependent manner in C57BL/6J mice engrafted with mT3 pancreatic cancer cells.
Physicochemical Properties
M.Wt
247.297
Formula
C17H13NO
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
4-(2-phenylpyridin-3-yl)phenol
References
1. Shahin Assefnia, et al. Oncotarget. 2014 Mar 30;5(6):1458-74.
2. Ivana Peran, et al. Gastroenterology. 2021 Mar;160(4):1359-1372.e13.
