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Chemical Structure : SD2758
Catalog No.: PC-23386Not For Human Use, Lab Use Only.
SD2758 is a small molecule inhibitor of GPR65, inhibits pH-dependent cAMP induction with sub-micromolar IC50 values at pH 7.5 and between 1 and 10 µM at pH 7.
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SD2758 is a small molecule inhibitor of GPR65, inhibits pH-dependent cAMP induction with sub-micromolar IC50 values at pH 7.5 and between 1 and 10 µM at pH 7.
SD2758 augments the cytotoxic activity of antigen-specific human T-cells.
GPR65 inhibition is associated with a higher production of pro-inflammatory cytokines.
| M.Wt | 379.24 | |
| Formula | C18H16Cl2N2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Shamin Li, et al. Front Immunol. 2024 Oct 17:15:1483258.
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