SD2758

Chemical Structure : SD2758

Catalog No.: PC-23386Not For Human Use, Lab Use Only.

SD2758 is a small molecule inhibitor of GPR65, inhibits pH-dependent cAMP induction with sub-micromolar IC50 values at pH 7.5 and between 1 and 10 µM at pH 7.

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Biological Activity

SD2758 is a small molecule inhibitor of GPR65, inhibits pH-dependent cAMP induction with sub-micromolar IC50 values at pH 7.5 and between 1 and 10 µM at pH 7.
SD2758 augments the cytotoxic activity of antigen-specific human T-cells.
GPR65 inhibition is associated with a higher production of pro-inflammatory cytokines.

Physicochemical Properties

M.Wt	379.24
Formula	C18H16Cl2N2O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	methyl 2-((3,4-dichlorophenyl)carbamoyl)-1,2,3,4-tetrahydroisoquinoline-6-carboxylate

References

1. Shamin Li, et al. Front Immunol. 2024 Oct 17:15:1483258.

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SD2758

Biological Activity

Physicochemical Properties

References

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