Chemical Structure : SDT-011
CAS No.:
500275-10-5
SDT-011
(SDT011)
Catalog No.: PC-20905Not For Human Use, Lab Use Only.
SDT-011 (SDT011) is a small molecule that effectively blocks the binding of anti-EGFR monoclonal antibodies to EGFR, blocks cetuximab-EGFR binding by 62% at 10 uM, binds to EGFR with Kd of 1.7 nM in MST assays.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
SDT-011 (SDT011) is a small molecule that effectively blocks the binding of anti-EGFR monoclonal antibodies to EGFR, blocks cetuximab-EGFR binding by 62% at 10 uM, binds to EGFR with Kd of 1.7 nM in MST assays.
SDT-011 does not bind cetuximab, interacts with the same residues on EGFR found to be important for the binding of EGFR mAbs cetuximab and panitumumab.
SDT-011 improves cell proliferation and EGFR activation in cell lines.
SDT-011 reactivates EGFR in ex vivo full human skin and in A431 injected mice.
SDT-011 can be delivered via a slow-release system derived from biodegradable nanoparticles that penetrate the hair follicles and sebaceous glands, within which EGFR is highly expressed.
Physicochemical Properties
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M.Wt
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333.33
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Formula
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C16H10F3N3S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N#CC1=C(N)C2=C(C(F)(F)F)C=C(C3=CC=C(C)C=C3)N=C2S1
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References
1. Nethanel Friedman, et al. Sci Transl Med. 2023 Jun 7;15(699):eabo0684.
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